Neurology Updates

Arbab et al. (2023) showed for the first time the feasibility of genome editing as permanently restoring SMN protein levels in cellular and animal…

A GAA repeat expansion in FGF14 appears to be an important and frequent cause of autosomal dominant late-onset cerebellar ataxia, further expanding…

RCTs to guide balancing the risks of seizures in pregnancy against the risks of developmental problems in babies exposed to ASMs are lacking. We…

MOGAD diagnostic criteria from the International MOGAD Panel

In patients with early AD, lecanemab, reduces brain amyloid levels and slows down cognitive decline by 27% over an 18 month period. However, it is…

A study in Canada has suggested that specialist palliative care involvement in the last year of life may reduce visits to emergency departments and…

Epstein-Barr virus infection is the strongest known risk factor for the development of multiple sclerosis, and it precedes preclinical manifestation…

The 2017 McDonald criteria showed higher sensitivity, lower specificity, and similar accuracy in predicting clinically definite multiple sclerosis…

Insidious disability accrual starts already in the earliest phases of multiple sclerosis and becomes dominant over the disease course, suggesting an…

In multiple sclerosis, an impairment of the glymphatic system may contribute to pathology accrual in the central nervous system and disability…

Baseline characteristics of Aβ-positive individuals can help identify those who will remain tau-negative for at least 5 years.

Greater diffusion restriction in the white matter of amyloid-beta-positive cognitively unimpaired individuals supports the role of inflammation in…