Neurology Updates

Neurology Updates

Here you will find regular scientific news from our Scientific Panels. We cover all areas of neurology, including rare diseases. The most recent news are displayed below. You will find all news of different areas sorted into the subsections of the respective scientific panel. Enjoy reading!

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| Neuroimmunology  

Archeological neuroimmunology- pathogenic immune response from a case of more than 60 years ago characterized from archival brain tissue

A medical mystery solved after more than 60 years- analysis of archival brain tissue allows characterization of rare fatal disease

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Created by Dr. Sonja Hochmeister

| Epilepsy  

Predicting seizures based on cyclical activity data using chronic electroencephalographic recordings (cEEG)

The major problem for epilepsy patients is unpredictability of seizures attacks, which carry a risk of accidents and has negative impact on normal…

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Created by Prof. Konrad Rejdak; Department of Neurology; Medical University of Lublin, Poland

| Rare Neurological Diseases  

Is treatment of SMA with onasemnogene abeparvovec associated with an immune response against the AAV vector?

The world has changed for patients and parents of children suffering from spinal muscular atrophy (SMA) type 1. Without treatment these children…

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Created by Marianne de Visser, Amsterdam University Medical Centres, Amsterdam, The Netherlands

| Rare Neurological Diseases  

Combination molecular therapies for type 1 spinal muscular atrophy

SMA is a perfect example of rare neurological disease, and should be regarded as a prototype concerning the medical and social aspects of its…

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Created by Dr. Tudor Lupescu, MD, PhD

| Dementia and cognitive disorders  

Association of Angiotensin-II stimulating antihypertensive use and dementia risk: Post hoc analysis of the preDIVA trial

Patients using angiotensin-II-stimulating antihypertensives have 45% lower risk to develop demenia compared to those that use…

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Created by Svetlana Tomic1,2, Zvonimir Popovic1,2, Francesco Di Lorenzo3,4

| Dementia and cognitive disorders  

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders

Study results suggest that RO948 F 18 has a high specificity for Alzheimer disease–type tau and highlight its potential as a diagnostic marker.

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Created by Svetlana Tomic1,2, Zvonimir Popovic1,2, Francesco Di Lorenzo3,4

| Dementia and cognitive disorders  

Blood phosphorylated tau 181 as a biomarker for Alzheimer’s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

Blood p-tau 181 is sensitive for identifying clinically diagnosed AD patients in the very early disease stages; differentiates AD from other…

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Created by Svetlana Tomic1,2, Zvonimir Popovic1,2, Francesco Di Lorenzo3,4

| Dementia and cognitive disorders  

Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes

Each AD phenotype had its own pattern of baseline and rates of change in tau pathology and grey matter loss, with some overlap particularly in the…

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Created by Svetlana Tomic1,2, Zvonimir Popovic1,2, Francesco Di Lorenzo3,4

| Coma & Chronic Disorders of Consciousness  

Auditory localisation could be considered as a new sign of the minimally conscious state

Auditory localization should be considered as a sign of consciousness, as unresponsive patients who demonstrate this behaviour show increased brain…

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Created by Manon Carrière, Coma Science Group, University of Liège and Centre du Cerveau2, University Hospital of Liège; Edited by Dr Leandro R. D. Sanz (SP Management Group)

| Coma & Chronic Disorders of Consciousness  

Discontinuation of artificial nutrition and hydration and covert cognition

The process of end-of-life decision-making for patients with disorders of consciousness should include caregivers in bedside assessments and integrate…

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Created by Rita Formisano, IRCCS, Santa Lucia Foundation, Rome; Edited by Dr Leandro R. D. Sanz (SP Management Group)

| Coma & Chronic Disorders of Consciousness  

Multi-center prospective study on predictors of short-term outcome in disorders of consciousness

An international study showed that younger age, shorter time since injury, higher level of responsiveness and EEG reactivity to eye opening are all…

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Created by Anna Estraneo, IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy; Neurology Unit, SM della Pietà General Hospital, Nola, Italy; Edited by Dr Leandro R. D. Sanz (SP Management Group)

| Coma & Chronic Disorders of Consciousness  

Habituation to auditory startle as a new sign of the minimally conscious state, and neurophysiological evidence for cortical effects of transcranial electric stimulation

Habituation of auditory startle reflex should be considered as a sign of the minimally conscious state, as unresponsive patients who demonstrate this…

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Created by Benjamin Rohaut, Sorbonne University and Pitié-Salpêtrière Hospital, Paris, France; Edited by Dr Leandro R. D. Sanz (SP Management Group)