Knowledge Distillery

In this open-label, multicentre, randomised clinical trial, recently published in JAMA, the authors evaluate the efficacy and adverse effects of…

In this article the authors combine cryo-EM, binding and computational analyses to study variant spikes, including one that was involved in…

Efficacy of Tocilizumab in Patients Hospitalized with COVID-19

This review, recently published in JAMA Neurology, serves to summarise available information regarding coronaviruses in the nervous system, identifies…

In this article the authors report cryo-EM structures of the full-length spike (S) trimers of the B.1.1.7 and B.1.351 variants, as well as their…

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia A Randomized Clinical Trial

One of the immediate and ongoing neurological challenges posed by the COVID-19 pandemic is the management of patients who are undergoing immunotherapy…

This randomized, double-blind, placebo-controlled phase 3 trial was conducted at 39 hospitals in Europe and the United States.

Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19

In this nice paper recently published in the European Journal of Neurology, the authors systematically reviewed available evidence for reports of…

The objective of this randomized clinical trial was to determine whether oral azithromycin in outpatients with SARS-CoV-2 infection leads to absence…

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia A Randomized Clinical Trial