Knowledge Distillery

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| Cross-sectional case-control studies  

Neurologic involvement in children and adolescents hospitalized in the United States for COVID-19 or multisystem inflammatory syndrome

COVID-19 affects the nervous system in adult patients. The spectrum of neurologic involvement in children and adolescents is unclear. The objective …

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Impact on neurological comorbidities

| Cross-sectional case-control studies  

Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19

Refinement of criteria for multisystem inflammatory syndrome in children (MIS-C) may inform efforts to improve health outcomes.

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Clinical and imaging features

| Case series/case reports  

Association of clinical, biological, and brain magnetic resonance imaging findings with electroencephalographic findings for patients with COVID-19

There is evidence of central nervous system impairments associated with COVID-19 infection, including encephalopathy.

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Clinical and imaging features

| Meta-analysis Systematic Review  

Association of convalescent plasma treatment with clinical outcomes in patients with COVID-19 a systematic review and meta-analysis

The objective of this article was to assess clinical outcomes with convalescent plasma treatment vs placebo or standard of care in peer-reviewed and…

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Therapeutics

| Cross-sectional case-control studies  

Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

SARS-CoV-2 lineage B.1.1.7, a variant first detected in the UK in September 2020, has spread to multiple countries worldwide.

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Clinical and imaging features

| Interventional study with open label/non-randomised methodology  

Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19, but evidence from community…

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Therapeutics

| Cross-sectional case-control studies  

Prevalence of mental disorders, suicidal ideation and suicides in the general population before and during the COVID-19 pandemic in Norway: A population-based repeated cross-sectional analysis

Self-report data on mental distress indicate a deterioration of population mental health in many countries during the COVID-19 pandemic.

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Impact on neurological comorbidities

| Interventional study with open label/non-randomised methodology  

Interleukin-6 receptor antagonists in critically ill patients with covid-19

The efficacy of interleukin-6 receptor antagonists in critically ill patients with COVID-19 is unclear. In this article the authors evaluated…

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Therapeutics

| Randomised double-blinded placebo-controlled trial  

Tocilizumab in hospitalized patients with severe COVID-19 pneumonia

COVID-19 is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal…

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Therapeutics