The authors included six studies (4 case-controlled studies and 2 cross-sectional studies) in the qualitative and quantitative syntheses. Authors found that the following factors were associated with COVID-19 in people with PD: obesity (OR: 1.79, 95% CI: 1.07 to 2.99, I2: 0%), any pulmonary disease (OR: 1.92, 95% CI: 1.17 to 3.15, I2: 0%), COVID-19 contact (OR: 41.77, 95% CI: 4.77 – 365.56, I2: 0%), vitamin D supplementation (OR: 0.50, 95% CI: 0.30 to 0.83, I2: 0%), hospitalization (OR: 11.78, 95% CI: 6.27 to 22.12, I2: 0%), and death (OR: 11.23, 95% CI: 3.92 to 32.18, I2: 0%). Authors did not find significant association between COVID-19 and hypertension, diabetes, cardiopathy, cancer, any cognitive problem, dementia, chronic obstructive pulmonary disease, renal or hepatic disease, smoking, and tremor. The authors concluded that meta-analyses were limited by the number of events and some methodological limitations. Despite that, the authors assessed available evidence, and the results may be useful in future health policies.
Chambergo-Michilot D, Barros-Sevillano S, Rivera-Torrejón O, De la Cruz-Ku GA, Custodio N. Factors associated with COVID-19 in people with Parkinson’s disease: a systematic review and meta-analysis. Eur J Neurol. 2021 May 13. doi: 10.1111/ene.14912.