It was l suggested a long time ago, that ALS is rather a cortical than a spinal disease. The work of Heiko Braak and collaborators has demonstrated neuropathological evidence that a cortical origin of the disease is a very likely one. This paper discusses this evidence from a translational perspective. It includes a discussion of the clinical syndrome of ALS, including frontal deficits and oculomotor involvement. Also, neuroimaging evidence is discussed from a translational perspective.
ALS, Motorcortex, Initiation and Propagation of ALS, extramotor involvement in ALS
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